Description
Product Characteristics:
Pinch is a focal adhesion protein that is a component of the ILK-PINCH complex. This complex is a major part of the growth factor and integrin signaling pathway. Pinch is involved in cell differentiation, proliferation and survival by acting as an effector of integrin and growth factor signaling. It is a cytoplasmic protein expressed in most tissues and consists of five LIM domains, a nuclear localization signal and a nuclear export signal. The PINCH-1/ILK complex is regulated by another member of the Pinch family, PINCH-2, which also forms a complex with ILK.
Subcellular location: Nucleus
Synonyms: FLJ10044, ILK binding protein, LIM and senescent cell antigen like domains 2, LIM and senescent cell antigen-like-containing domain protein 2, LIM-like protein 2, LIMS2, LIMS2_HUMAN, Particularly interesting new Cys-His protein 2, PINCH 2, PINCH-2, PINCH2.
Target Information: This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]